Polynucleotides
Repair your skin from within.
Regenerative injectables that help your skin repair itself, for stronger, healthier skin that still looks completely like you.
What are polynucleotides?
Polynucleotides (often shortened to PN) are purified fragments of DNA, usually derived from salmon or salmon trout. Their structure is highly compatible with human tissue, which is why they are so well tolerated.
Once placed in the skin, polynucleotides act as a signal to your own cells. They support the fibroblasts that produce collagen and elastin, help the skin hold on to moisture and calm inflammation. Over a course of treatments, skin becomes thicker, firmer, smoother and more even in tone.
Polynucleotides are not a filler and do not change the shape of your face. They are a skin-quality treatment, ideal if you want to look well rested and healthy rather than "done".
Polynucleotides can help with:
- Crêpey skin, fine lines and dark circles under the eyes
- Dull, dehydrated or tired-looking skin
- Loss of firmness and elasticity
- Acne scarring and uneven texture
- Redness and sensitive skin
- Crêpiness on the neck and décolletage
Rejuran Healer.
Developed in South Korea, where it has become a staple of skin care, Rejuran uses polynucleotides derived from purified salmon DNA to switch on your skin's own repair process.
We use Rejuran Healer across the full face for overall skin quality, and Rejuran i, a formulation made specifically for the delicate eye area, to help with crêpiness, fine lines and that tired, hollow look.
- Improves skin texture, thickness and elasticity
- Boosts hydration for a healthier, more even complexion
- Helps soften fine lines and crêpey skin
- Calms redness and supports a stronger skin barrier
- Refreshes the delicate under-eye area
DermaFocus Polynucleotides.
DermaFocus, known as the home of polynucleotides in the UK, brings us the Plinest range: highly purified polynucleotides from salmon trout DNA, made in Italy and backed by one of the longest clinical track records of any polynucleotide.
The range includes treatments for the face, a dedicated formulation for the eye area, and Newest, which pairs polynucleotides with hyaluronic acid for an extra boost of hydration. That flexibility means Izzi can match your treatment precisely to your skin.
- Strengthens and regenerates thinning, tired skin
- Improves firmness, tone and elasticity
- Deep hydration, especially with Newest
- Brightens dark circles and crêpiness around the eyes
- A natural improvement with no added volume
Your questions answered.
Are polynucleotides the same as fillers?
No. Fillers add volume and change shape. Polynucleotides work on the quality of your skin, helping it repair, strengthen and hydrate itself. They won't change your features, which is why results look so natural.
Does it hurt?
We apply numbing cream beforehand, so most people find it very manageable. You'll feel a series of small scratches, and the treatment is over quickly.
How many sessions will I need?
We usually recommend a course of three treatments spaced a few weeks apart, followed by a maintenance session every six to nine months to keep your skin at its best.
When will I see results?
Many clients notice their skin looks fresher and more hydrated within a few weeks of the first session. Because polynucleotides work with your skin's natural renewal, the best results build gradually over the course.
Is it suitable for everyone?
Polynucleotides suit most skin types, but they are not suitable if you have a fish or salmon allergy, are pregnant or breastfeeding, or have an active skin infection in the treatment area. Izzi will go through your medical history fully at consultation.
Can I combine polynucleotides with other treatments?
Yes. They pair beautifully with skin boosters, anti-wrinkle injections and our laser treatments. Our Tired Eyes Duo package combines Rejuran with a clinical-grade eye cream for even better results.
How does the consultation work?
Your consultation with Izzi costs £50 and is fully redeemable against your treatment. She'll assess your skin, talk through your goals and medical history, and recommend the right treatment or combination for you. There's never any pressure to book on the day.